Monkeypox: Developers of the only licensed vaccine are ready to meet the demand

“The approval (from the US health authorities) received in 2019 (…) has suddenly become very, very relevant to international health,” Rolf Sass Sørensen, vice president, smiles at the biotech headquarters in the port of Copenhagen. Bavarian Norse. Surprised by the spread of the disease outside the 11 West and Central African countries where it is endemic, he nonetheless says he can meet demand, even with just one production plant.

“With the current demand, we can easily supply the global market. We have a few million doses in bulk, we can bottle them and make sure the current outbreak is addressed,” he explains.

Bavarian Nordic has an annual production capacity of 30 million doses at its factory north of the Nordic capital. Its smallpox vaccine is a third-generation serum, that is, a non-replicating live vaccine (which does not replicate in the human body), marketed under the name Imvanex in Europe where it has been authorized since 2013, by Jynneos in the United States. . States and Imvamune in Canada.

many actions

Indicated for the first time against smallpox in adults, a disease considered eradicated for about forty years, the treatment requires two doses.

According to Rolf Sass Sørensen, the vaccine is “available in many countries” and can be applied before or after exposure to the disease. “If you get vaccinated within a few days of being exposed, you can also be protected,” he says.

After getting the green light from US authorities three years ago, Bavarian Nordic is working to expand its European registry for monkeypox.

Within the EU, the Hera health authority (created in the wake of the covid-19 pandemic) has procured almost 100,000 vaccines that will be made available to the 27, as well as to Norway and Iceland. The first deliveries are expected by the end of June for priority countries, European authorities said.

The United States also announced that it had replenished its stockpiles with an additional 500,000 doses in addition to 100 million units of another smallpox vaccine from France’s Sanofi. Canada and Denmark have done the same.

Beyond these announcements, the Danish laboratory jealously protects the nationality of its sponsors. “We don’t reveal the names of the countries, but we have requests from all over the world: the United States, European countries, Asian countries, the Middle East,” says Rolf Sass Sørensen.

The amounts of the contracts have not been made public either, but for Bavarian Nordic, it is a stroke of luck that has allowed it to raise its forecasts for 2022 four times in three weeks.

No mass vaccination

Despite the exponential increase in cases, the WHO does not recommend “mass” vaccination at this stage.

In France, the High Health Authority has recommended administering a single dose of the vaccine to people who are risk contacts and have been vaccinated against smallpox before 1980, except immunosuppressed people.

The United States has vaccination of contact cases.

A smallpox drug, tecovirimat, produced by the Siga laboratory, was approved by the EMA for monkeypox earlier this year, but is not yet widely available.

Most often mild, the illness usually clears up on its own, after two to three weeks of flu-like symptoms followed by rashes.

From January 1 to June 15, more than 2,103 cases and one death have been reported to the WHO in 42 countries. Europe is at the center of the spread of the virus, with 1,773 confirmed cases, or 84% of the global total.

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