Monkeypox: recommendations for donations of human body products

In France, on June 6, 2022, there were 66 confirmed cases of human infection with the monkeypox virus (monkeypox virus – MPXV). Given that the dynamics of this virus is unknown, the General Directorate of Health asked the Superior Council of Public Health (HCSP) what measures should be taken to prevent the transmission of this virus by blood products, grafts and other products and elements of the human being. body (PCH – products of the human body).

In its recommendations, the HCSP distinguishes several types of donors.

Contact patients who received the Imvanex© vaccine (live smallpox vaccine that does not replicate in the human body) are excluded from PCH donation for a period of 4 weeks after the last dose of the vaccine, regardless of other preventive measures. If a vaccinated subject becomes a contact case again, it should be deferred 21 days from the date of last contact.

Blood donors and blood products:

  • having had a confirmed, probable or suspected MPXV infection: donation postponed for 42 days (corresponding to twice the maximum incubation period), from the date of appearance of clinical signs;

  • identified as confirmed, probable, or suspected contact cases: 21-day suspension from date of last contact.

Living donors of organs, tissues and hematopoietic stem cells:

  • having had a confirmed, probable or suspected MPXV infection: donation postponed for 42 days, from the date of appearance of clinical signs;

  • identified as confirmed, probable, or suspected contact cases: 21-day suspension from date of last contact.

deceased donors should be investigated for confirmed, probable, or suspected MPXV infection. If there are elements in their favor, donations should definitely be excluded.

For medically assisted procreationpeople :

  • having had a confirmed MPXV infection: donation deferred for 42 days, from the date of onset of clinical signs;

  • identified as confirmed, probable, or suspected contact cases: 21-day suspension from date of last contact.

For the preservation of fertility., the HCSP recommends postponing the sample whenever possible.

For therapeutic lactation, a respective postponement of 42 days and 21 days is recommended for cases of infection and MPXV contacts.

These recommendations are based on an argument that distinguishes between ” areas of concern » (in particular, the many unknowns about the origin and modalities of contamination, as well as about the pathophysiology of the disease) and « reassuring elements (in particular the existence of a specific PCR test “ quite easy and quick to implement »).

Questions directed at potential donors will focus on notions of recent travel and multiple sexual partners, as well as:

  • the presence of an ongoing infectious syndrome or in the previous 15 days,

  • the presence of a skin lesion or infection in the previous 15 days,

  • contact with a person with a contagious disease in the last month.

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