blood transfusions to reduce disease?

THE ESSENTIAL

  • Only 1.2 to 2% of Alzheimer’s disease cases are hereditary according to Inserm.
  • Before the age of 65 it is very rare to develop this disease, but after the age of 80 the prevalence increases.

1.2 million people suffer from Alzheimer’s disease in France, according to thehealth insurance. This neurodegenerative pathology is the most common in France. Of twenty-five patients, fifteen are women and ten are men according to National Institute of Health and Medical Research (Insert).

No treatment

Currently, there is no cure for Alzheimer’s disease. But researchers at the University of Texas in the United States may have found a new solution to reduce patients’ symptoms: blood transfusions. Their results have just been published in the journal Molecular Psychiatry.

amyloid beta peptides

The scientists conducted their experiments on mice that had amyloid beta peptides in their blood, which is one of the signs of Alzheimer’s disease. So the researchers wanted to know if changing your blood, thereby removing amyloid beta peptides, could reduce your Alzheimer’s symptoms.

spatial memory

Therefore, on several occasions, the mice received blood transfusions. Results: the development of amyloid plaques was reduced between 40 and 80%. These amyloid peptide plaquesThey form around neurons and prevent them, among other things, from working properly.

Another benefit of these transplants: the reduction of certain symptoms of the disease in rodents, such as the improvement of their spatial memory.

Treat disease…

This article provides a proof of concept for the use of technologies commonly used in medical practice, such as plasmapheresis or blood dialysis, which could “clean” the blood of patients with Alzheimer’s disease, thus reducing the accumulation of substances toxic to the brain.explains Claudio Soto, one of the authors of this study. This approach has the advantage of being able to treat the disease in the circulation rather than in the brain.”.

…in a few years

The researchers now intend to continue their research so that they can offer this solution to patients and improve their quality of life. In fact, the main symptoms of Alzheimer’s disease are memory loss (recent and old), problems performing everyday gestures such as not knowing how to prepare a meal, temporal and spatial disorientation, mood and sleep disorders, etc. .

From here By 2050, the number of people with Alzheimer’s should be more than 2.2 million, or 3.31% of the French population, according to the Alzheimer Foundation.


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